In collaboration with the research team of the Institute of Radiology at the Charité Berlin led by Prof. Ingolf Sack, GAMPT is developing new medical diagnostic methods (THED) for the non-invasive examination of organs using the time-harmonic elastography method (THE).
Recently, the research team was able to measure the cerebral stiffness. Until now, this diagnosis could only be achieved using the risky pressure measurement of the cerebral fluid by drilling a hole into the cranial cavity. The physiological mechanisms leading to the change in stiffness are attributed to the cerebral-vascular reactivity, cerebral blood flow activity and intracranial regulation.
The results of the pilot study were published in the following articles:
Time-Resolved Response of Cerebral Stiffness to Hypercapnia in Humans
Kreft B, Tzschätzsch H, Schrank F, Bergs J, Streitberger KJ, Wäldchen S, Hetzer S, Braun J, Sack I., Ultrasound Med Biol. 2020 Apr;46(4):936-943. doi: 10.1016/j.ultrasmedbio.2019.12.019. Epub 2020 Jan 28
In vivo time-harmonic ultrasound elastography of the human brain detects acute cerebral stiffness changes induced by intracranial pressure variations
Tzschatzsch, H., Kreft, B., Schrank, F., Bergs, J., Braun, J. & Sack, I., Sci Rep 8, 17888, doi:10.1038/s41598-018-36191-9 (2018).
If you are interested in the publications, please contact: ingolf.sack@charite.de
The mentioned measurement technology is commercially available for clinical research teams. For details please contact: Dr. Grit Oblonczek
